Eintrag weiter verarbeiten
Ataxin-2 Interacts with the DEAD/H-Box RNA Helicase DDX6 and Interferes with P-Bodies and Stress Granules
Gespeichert in:
| Zeitschriftentitel: | Molecular Biology of the Cell |
|---|---|
| Personen und Körperschaften: | , , , , , , , |
| In: | Molecular Biology of the Cell, 18, 2007, 4, S. 1385-1396 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Society for Cell Biology (ASCB)
|
| Schlagwörter: |
| author_facet |
Nonhoff, Ute Ralser, Markus Welzel, Franziska Piccini, Ilaria Balzereit, Daniela Yaspo, Marie-Laure Lehrach, Hans Krobitsch, Sylvia Nonhoff, Ute Ralser, Markus Welzel, Franziska Piccini, Ilaria Balzereit, Daniela Yaspo, Marie-Laure Lehrach, Hans Krobitsch, Sylvia |
|---|---|
| author |
Nonhoff, Ute Ralser, Markus Welzel, Franziska Piccini, Ilaria Balzereit, Daniela Yaspo, Marie-Laure Lehrach, Hans Krobitsch, Sylvia |
| spellingShingle |
Nonhoff, Ute Ralser, Markus Welzel, Franziska Piccini, Ilaria Balzereit, Daniela Yaspo, Marie-Laure Lehrach, Hans Krobitsch, Sylvia Molecular Biology of the Cell Ataxin-2 Interacts with the DEAD/H-Box RNA Helicase DDX6 and Interferes with P-Bodies and Stress Granules Cell Biology Molecular Biology |
| author_sort |
nonhoff, ute |
| spelling |
Nonhoff, Ute Ralser, Markus Welzel, Franziska Piccini, Ilaria Balzereit, Daniela Yaspo, Marie-Laure Lehrach, Hans Krobitsch, Sylvia 1059-1524 1939-4586 American Society for Cell Biology (ASCB) Cell Biology Molecular Biology http://dx.doi.org/10.1091/mbc.e06-12-1120 <jats:p>Tight control of translation is fundamental for eukaryotic cells, and deregulation of proteins implicated contributes to numerous human diseases. The neurodegenerative disorder spinocerebellar ataxia type 2 is caused by a trinucleotide expansion in the SCA2 gene encoding a lengthened polyglutamine stretch in the gene product ataxin-2, which seems to be implicated in cellular RNA-processing pathways and translational regulation. Here, we substantiate a function of ataxin-2 in such pathways by demonstrating that ataxin-2 interacts with the DEAD/H-box RNA helicase DDX6, a component of P-bodies and stress granules, representing cellular structures of mRNA triage. We discovered that altered ataxin-2 levels interfere with the assembly of stress granules and cellular P-body structures. Moreover, ataxin-2 regulates the intracellular concentration of its interaction partner, the poly(A)-binding protein, another stress granule component and a key factor for translational control. Thus, our data imply that the cellular ataxin-2 concentration is important for the assembly of stress granules and P-bodies, which are main compartments for regulating and controlling mRNA degradation, stability, and translation.</jats:p> Ataxin-2 Interacts with the DEAD/H-Box RNA Helicase DDX6 and Interferes with P-Bodies and Stress Granules Molecular Biology of the Cell |
| doi_str_mv |
10.1091/mbc.e06-12-1120 |
| facet_avail |
Online Free |
| finc_class_facet |
Biologie |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTA5MS9tYmMuZTA2LTEyLTExMjA |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTA5MS9tYmMuZTA2LTEyLTExMjA |
| institution |
DE-Gla1 DE-Zi4 DE-15 DE-Pl11 DE-Rs1 DE-105 DE-14 DE-Ch1 DE-L229 DE-D275 DE-Bn3 DE-Brt1 DE-Zwi2 DE-D161 |
| imprint |
American Society for Cell Biology (ASCB), 2007 |
| imprint_str_mv |
American Society for Cell Biology (ASCB), 2007 |
| issn |
1059-1524 1939-4586 |
| issn_str_mv |
1059-1524 1939-4586 |
| language |
English |
| mega_collection |
American Society for Cell Biology (ASCB) (CrossRef) |
| match_str |
nonhoff2007ataxin2interactswiththedeadhboxrnahelicaseddx6andinterfereswithpbodiesandstressgranules |
| publishDateSort |
2007 |
| publisher |
American Society for Cell Biology (ASCB) |
| recordtype |
ai |
| record_format |
ai |
| series |
Molecular Biology of the Cell |
| source_id |
49 |
| title |
Ataxin-2 Interacts with the DEAD/H-Box RNA Helicase DDX6 and Interferes with P-Bodies and Stress Granules |
| title_unstemmed |
Ataxin-2 Interacts with the DEAD/H-Box RNA Helicase DDX6 and Interferes with P-Bodies and Stress Granules |
| title_full |
Ataxin-2 Interacts with the DEAD/H-Box RNA Helicase DDX6 and Interferes with P-Bodies and Stress Granules |
| title_fullStr |
Ataxin-2 Interacts with the DEAD/H-Box RNA Helicase DDX6 and Interferes with P-Bodies and Stress Granules |
| title_full_unstemmed |
Ataxin-2 Interacts with the DEAD/H-Box RNA Helicase DDX6 and Interferes with P-Bodies and Stress Granules |
| title_short |
Ataxin-2 Interacts with the DEAD/H-Box RNA Helicase DDX6 and Interferes with P-Bodies and Stress Granules |
| title_sort |
ataxin-2 interacts with the dead/h-box rna helicase ddx6 and interferes with p-bodies and stress granules |
| topic |
Cell Biology Molecular Biology |
| url |
http://dx.doi.org/10.1091/mbc.e06-12-1120 |
| publishDate |
2007 |
| physical |
1385-1396 |
| description |
<jats:p>Tight control of translation is fundamental for eukaryotic cells, and deregulation of proteins implicated contributes to numerous human diseases. The neurodegenerative disorder spinocerebellar ataxia type 2 is caused by a trinucleotide expansion in the SCA2 gene encoding a lengthened polyglutamine stretch in the gene product ataxin-2, which seems to be implicated in cellular RNA-processing pathways and translational regulation. Here, we substantiate a function of ataxin-2 in such pathways by demonstrating that ataxin-2 interacts with the DEAD/H-box RNA helicase DDX6, a component of P-bodies and stress granules, representing cellular structures of mRNA triage. We discovered that altered ataxin-2 levels interfere with the assembly of stress granules and cellular P-body structures. Moreover, ataxin-2 regulates the intracellular concentration of its interaction partner, the poly(A)-binding protein, another stress granule component and a key factor for translational control. Thus, our data imply that the cellular ataxin-2 concentration is important for the assembly of stress granules and P-bodies, which are main compartments for regulating and controlling mRNA degradation, stability, and translation.</jats:p> |
| container_issue |
4 |
| container_start_page |
1385 |
| container_title |
Molecular Biology of the Cell |
| container_volume |
18 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792348009363668997 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T18:04:22.081Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Ataxin-2+Interacts+with+the+DEAD%2FH-Box+RNA+Helicase+DDX6+and+Interferes+with+P-Bodies+and+Stress+Granules&rft.date=2007-04-01&genre=article&issn=1939-4586&volume=18&issue=4&spage=1385&epage=1396&pages=1385-1396&jtitle=Molecular+Biology+of+the+Cell&atitle=Ataxin-2+Interacts+with+the+DEAD%2FH-Box+RNA+Helicase+DDX6+and+Interferes+with+P-Bodies+and+Stress+Granules&aulast=Krobitsch&aufirst=Sylvia&rft_id=info%3Adoi%2F10.1091%2Fmbc.e06-12-1120&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792348009363668997 |
| author | Nonhoff, Ute, Ralser, Markus, Welzel, Franziska, Piccini, Ilaria, Balzereit, Daniela, Yaspo, Marie-Laure, Lehrach, Hans, Krobitsch, Sylvia |
| author_facet | Nonhoff, Ute, Ralser, Markus, Welzel, Franziska, Piccini, Ilaria, Balzereit, Daniela, Yaspo, Marie-Laure, Lehrach, Hans, Krobitsch, Sylvia, Nonhoff, Ute, Ralser, Markus, Welzel, Franziska, Piccini, Ilaria, Balzereit, Daniela, Yaspo, Marie-Laure, Lehrach, Hans, Krobitsch, Sylvia |
| author_sort | nonhoff, ute |
| container_issue | 4 |
| container_start_page | 1385 |
| container_title | Molecular Biology of the Cell |
| container_volume | 18 |
| description | <jats:p>Tight control of translation is fundamental for eukaryotic cells, and deregulation of proteins implicated contributes to numerous human diseases. The neurodegenerative disorder spinocerebellar ataxia type 2 is caused by a trinucleotide expansion in the SCA2 gene encoding a lengthened polyglutamine stretch in the gene product ataxin-2, which seems to be implicated in cellular RNA-processing pathways and translational regulation. Here, we substantiate a function of ataxin-2 in such pathways by demonstrating that ataxin-2 interacts with the DEAD/H-box RNA helicase DDX6, a component of P-bodies and stress granules, representing cellular structures of mRNA triage. We discovered that altered ataxin-2 levels interfere with the assembly of stress granules and cellular P-body structures. Moreover, ataxin-2 regulates the intracellular concentration of its interaction partner, the poly(A)-binding protein, another stress granule component and a key factor for translational control. Thus, our data imply that the cellular ataxin-2 concentration is important for the assembly of stress granules and P-bodies, which are main compartments for regulating and controlling mRNA degradation, stability, and translation.</jats:p> |
| doi_str_mv | 10.1091/mbc.e06-12-1120 |
| facet_avail | Online, Free |
| finc_class_facet | Biologie |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTA5MS9tYmMuZTA2LTEyLTExMjA |
| imprint | American Society for Cell Biology (ASCB), 2007 |
| imprint_str_mv | American Society for Cell Biology (ASCB), 2007 |
| institution | DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161 |
| issn | 1059-1524, 1939-4586 |
| issn_str_mv | 1059-1524, 1939-4586 |
| language | English |
| last_indexed | 2024-03-01T18:04:22.081Z |
| match_str | nonhoff2007ataxin2interactswiththedeadhboxrnahelicaseddx6andinterfereswithpbodiesandstressgranules |
| mega_collection | American Society for Cell Biology (ASCB) (CrossRef) |
| physical | 1385-1396 |
| publishDate | 2007 |
| publishDateSort | 2007 |
| publisher | American Society for Cell Biology (ASCB) |
| record_format | ai |
| recordtype | ai |
| series | Molecular Biology of the Cell |
| source_id | 49 |
| spelling | Nonhoff, Ute Ralser, Markus Welzel, Franziska Piccini, Ilaria Balzereit, Daniela Yaspo, Marie-Laure Lehrach, Hans Krobitsch, Sylvia 1059-1524 1939-4586 American Society for Cell Biology (ASCB) Cell Biology Molecular Biology http://dx.doi.org/10.1091/mbc.e06-12-1120 <jats:p>Tight control of translation is fundamental for eukaryotic cells, and deregulation of proteins implicated contributes to numerous human diseases. The neurodegenerative disorder spinocerebellar ataxia type 2 is caused by a trinucleotide expansion in the SCA2 gene encoding a lengthened polyglutamine stretch in the gene product ataxin-2, which seems to be implicated in cellular RNA-processing pathways and translational regulation. Here, we substantiate a function of ataxin-2 in such pathways by demonstrating that ataxin-2 interacts with the DEAD/H-box RNA helicase DDX6, a component of P-bodies and stress granules, representing cellular structures of mRNA triage. We discovered that altered ataxin-2 levels interfere with the assembly of stress granules and cellular P-body structures. Moreover, ataxin-2 regulates the intracellular concentration of its interaction partner, the poly(A)-binding protein, another stress granule component and a key factor for translational control. Thus, our data imply that the cellular ataxin-2 concentration is important for the assembly of stress granules and P-bodies, which are main compartments for regulating and controlling mRNA degradation, stability, and translation.</jats:p> Ataxin-2 Interacts with the DEAD/H-Box RNA Helicase DDX6 and Interferes with P-Bodies and Stress Granules Molecular Biology of the Cell |
| spellingShingle | Nonhoff, Ute, Ralser, Markus, Welzel, Franziska, Piccini, Ilaria, Balzereit, Daniela, Yaspo, Marie-Laure, Lehrach, Hans, Krobitsch, Sylvia, Molecular Biology of the Cell, Ataxin-2 Interacts with the DEAD/H-Box RNA Helicase DDX6 and Interferes with P-Bodies and Stress Granules, Cell Biology, Molecular Biology |
| title | Ataxin-2 Interacts with the DEAD/H-Box RNA Helicase DDX6 and Interferes with P-Bodies and Stress Granules |
| title_full | Ataxin-2 Interacts with the DEAD/H-Box RNA Helicase DDX6 and Interferes with P-Bodies and Stress Granules |
| title_fullStr | Ataxin-2 Interacts with the DEAD/H-Box RNA Helicase DDX6 and Interferes with P-Bodies and Stress Granules |
| title_full_unstemmed | Ataxin-2 Interacts with the DEAD/H-Box RNA Helicase DDX6 and Interferes with P-Bodies and Stress Granules |
| title_short | Ataxin-2 Interacts with the DEAD/H-Box RNA Helicase DDX6 and Interferes with P-Bodies and Stress Granules |
| title_sort | ataxin-2 interacts with the dead/h-box rna helicase ddx6 and interferes with p-bodies and stress granules |
| title_unstemmed | Ataxin-2 Interacts with the DEAD/H-Box RNA Helicase DDX6 and Interferes with P-Bodies and Stress Granules |
| topic | Cell Biology, Molecular Biology |
| url | http://dx.doi.org/10.1091/mbc.e06-12-1120 |