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Beta-trace protein as a new non-invasive immunological marker for quinolinic acid-induced impaired blood-brain barrier integrity

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Veröffentlicht in: Scientific reports 7(2017) Artikel-Nummer 43642, 8 Seiten
Personen und Körperschaften: Baranyi, Andreas (VerfasserIn), März, Winfried (VerfasserIn)
Titel: Beta-trace protein as a new non-invasive immunological marker for quinolinic acid-induced impaired blood-brain barrier integrity/ Andreas Baranyi, Omid Amouzadeh-Ghadikolai, Dirk von Lewinski, Robert J. Breitenecker, Tatjana Stojakovic, Winfried März, Christoph Robier, Hans-Bernd Rothenhäusler, Harald Mangge & Andreas Meinitzer
Format: E-Book-Kapitel
Sprache: Englisch
veröffentlicht:
09 March 2017
Gesamtaufnahme: : Scientific reports, 7(2017) Artikel-Nummer 43642, 8 Seiten
, volume:7
Quelle: Verbunddaten SWB
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Zusammenfassung: Quinolinic acid, a macrophage/microglia-derived excitotoxin fulfills a plethora of functions such as neurotoxin, gliotoxin, and proinflammatory mediator, and it alters the integrity and cohesion of the blood-brain barrier in several pathophysiological states. Beta-trace protein (BTP), a monomeric glycoprotein, is known to indicate cerebrospinal fluid leakage. Thus, the prior aim of this study was to investigate whether BTP might non-invasively indicate quinolinic acid-induced impaired blood-brain barrier integrity. The research hypotheses were tested in three subsamples with different states of immune activation (patients with HCV-infection and interferon-α, patients with major depression, and healthy controls). BTP has also been described as a sensitive marker in detecting impaired renal function. Thus, the renal function has been considered. Our study results revealed highest quinolinic acid and highest BTP- levels in the subsample of patients with HCV in comparison with the other subsamples with lower or no immune activation (quinolinic acid: F = 21.027, p < 0.001 [ANOVA]; BTP: F = 6.792, p < 0.01 [ANOVA]). In addition, a two-step hierarchical linear regression model showed that significant predictors of BTP levels are quinolinic acid, glomerular filtration rate and age. The neurotoxin quinolinic acid may impair blood-brain barrier integrity. BTP might be a new non-invasive biomarker to indicate quinolinic acid-induced impaired blood-brain barrier integrity.
Beschreibung: Gesehen am 19.08.2018
Umfang: 8
ISSN: 2045-2322
DOI: 10.1038/srep43642