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Dissecting the genomic complexity underlying medulloblastoma

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Veröffentlicht in: Nature <London> 488(2012), 7409, Seite 100-105
Personen und Körperschaften: Jones, David T. W. (VerfasserIn), Jäger, Natalie (VerfasserIn), Kool, Marcel (VerfasserIn), Zichner, Thomas (VerfasserIn), Hutter, Barbara (VerfasserIn), Sultan, Marc (VerfasserIn), Cho, Yoon-Jae (VerfasserIn), Pugh, Trevor (VerfasserIn), Hovestadt, Volker (VerfasserIn), Stütz, Adrian M. (VerfasserIn), Rausch, Tobias (VerfasserIn), Warnatz, Hans-Jörg (VerfasserIn), Ryzhova, Marina (VerfasserIn), Bender, Sebastian (VerfasserIn), Sturm, Dominik (VerfasserIn), Pleier, Sabrina Valesca (VerfasserIn), Şeker-Cin, Huriye (VerfasserIn), Pfaff, Elke Katrin (VerfasserIn), Sieber, Laura (VerfasserIn), Wittmann, Andrea (VerfasserIn), Remke, Marc (VerfasserIn), Witt, Hendrik (VerfasserIn), Hutter, Sonja (VerfasserIn), Tzaridis, Theophilos-Dimitrios (VerfasserIn), Weischenfeldt, Joachim (VerfasserIn), Zapatka, Marc (VerfasserIn), Bartholomä, Cynthia C. (VerfasserIn), Schmidt, Manfred (VerfasserIn), Kalle, Christof von (VerfasserIn), Ast, Volker (VerfasserIn), Lawerenz, Christian (VerfasserIn), Eils, Jürgen (VerfasserIn), Betts, Matthew J. (VerfasserIn), Russell, Robert B. (VerfasserIn), Roggendorf, Wolfgang (VerfasserIn), Unterberg, Andreas (VerfasserIn), Herold-Mende, Christel (VerfasserIn), Milde, Till (VerfasserIn), Kulozik, Andreas (VerfasserIn), Deimling, Andreas von (VerfasserIn), Witt, Olaf (VerfasserIn), Rutkowski, Stefan (VerfasserIn), Bueren, André von (VerfasserIn), Brors, Benedikt (VerfasserIn), Korbel, Jan Oliver (VerfasserIn), Korshunov, Andrey (VerfasserIn), Eils, Roland (VerfasserIn), Pfister, Stefan (VerfasserIn), Lichter, Peter (VerfasserIn)
Titel: Dissecting the genomic complexity underlying medulloblastoma/ David T.W. Jones, Natalie Jäger, Marcel Kool, Thomas Zichner, Barbara Hutter, Marc Sultan, Yoon-Jae Cho, Trevor J. Pugh, Volker Hovestadt, Adrian M. Stütz, Tobias Rausch, Hans-Jörg Warnatz, Marina Ryzhova, Sebastian Bender, Dominik Sturm, Sabrina Pleier, Huriye Cin, Elke Pfaff, Laura Sieber, Andrea Wittmann, Marc Remke, Hendrik Witt, Sonja Hutter, Theophilos Tzaridis, Joachim Weischenfeldt, Benjamin Raeder, Meryem Avci, Vyacheslav Amstislavskiy, Marc Zapatka, Ursula D. Weber, Qi Wang, Bärbel Lasitschka, Cynthia C. Bartholomae, Manfred Schmidt, Christof von Kalle, Volker Ast, Chris Lawerenz, Jürgen Eils, Rolf Kabbe, Vladimir Benes, Peter van Sluis, Jan Koster, Richard Volckmann, David Shih, Matthew J. Betts, Robert B. Russell, Simona Coco, Gian Paolo Tonini, Ulrich Schüller, Volkmar Hans, Norbert Graf, Yoo-Jin Kim, Camelia Monoranu, Wolfgang Roggendorf, Andreas Unterberg, Christel Herold-Mende, Till Milde, Andreas E. Kulozik, Andreas von Deimling, Olaf Witt, Eberhard Maass, Jochen Rössler, Martin Ebinger, Martin U. Schuhmann, Michael C. Frühwald, Martin Hasselblatt, Nada Jabado, Stefan Rutkowski, André O. von Bueren, Dan Williamson, Steven C. Clifford, Martin G. McCabe, V. Peter Collins, Stephan Wolf, Stefan Wiemann, Hans Lehrach, Benedikt Brors, Wolfram Scheurlen, Jörg Felsberg, Guido Reifenberger, Paul A. Northcott, Michael D. Taylor, Matthew Meyerson, Scott L. Pomeroy, Marie-Laure Yaspo, Jan O. Korbel, Andrey Korshunov, Roland Eils, Stefan M. Pfister, Peter Lichter
Format: E-Book-Kapitel
Sprache: Englisch
veröffentlicht:
25 July 2012
Gesamtaufnahme: : Nature <London>, 488(2012), 7409, Seite 100-105
, volume:488
Erscheint auch als: Jones, David T. W., Dissecting the genomic complexity underlying medulloblastoma, 2012
Quelle: Verbunddaten SWB
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520 |a Medulloblastoma is an aggressively growing tumour, arising in the cerebellum or medulla/brain stem. It is the most common malignant brain tumour in children, and shows tremendous biological and clinical heterogeneity1. Despite recent treatment advances, approximately 40% of children experience tumour recurrence, and 30% will die from their disease. Those who survive often have a significantly reduced quality of life. Four tumour subgroups with distinct clinical, biological and genetic profiles are currently identified2,3. WNT tumours, showing activated wingless pathway signalling, carry a favourable prognosis under current treatment regimens4. SHH tumours show hedgehog pathway activation, and have an intermediate prognosis2. Group 3 and 4 tumours are molecularly less well characterized, and also present the greatest clinical challenges2,3,5. The full repertoire of genetic events driving this distinction, however, remains unclear. Here we describe an integrative deep-sequencing analysis of 125 tumour-normal pairs, conducted as part of the International Cancer Genome Consortium (ICGC) PedBrain Tumor Project. Tetraploidy was identified as a frequent early event in Group 3 and 4 tumours, and a positive correlation between patient age and mutation rate was observed. Several recurrent mutations were identified, both in known medulloblastoma-related genes (CTNNB1, PTCH1, MLL2, SMARCA4) and in genes not previously linked to this tumour (DDX3X, CTDNEP1, KDM6A, TBR1), often in subgroup-specific patterns. RNA sequencing confirmed these alterations, and revealed the expression of what are, to our knowledge, the first medulloblastoma fusion genes identified. Chromatin modifiers were frequently altered across all subgroups. These findings enhance our understanding of the genomic complexity and heterogeneity underlying medulloblastoma, and provide several potential targets for new therapeutics, especially for Group 3 and 4 patients. 
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author Jones, David T. W., Jäger, Natalie, Kool, Marcel, Zichner, Thomas, Hutter, Barbara, Sultan, Marc, Cho, Yoon-Jae, Pugh, Trevor, Hovestadt, Volker, Stütz, Adrian M., Rausch, Tobias, Warnatz, Hans-Jörg, Ryzhova, Marina, Bender, Sebastian, Sturm, Dominik, Pleier, Sabrina Valesca, Şeker-Cin, Huriye, Pfaff, Elke Katrin, Sieber, Laura, Wittmann, Andrea, Remke, Marc, Witt, Hendrik, Hutter, Sonja, Tzaridis, Theophilos-Dimitrios, Weischenfeldt, Joachim, Zapatka, Marc, Bartholomä, Cynthia C., Schmidt, Manfred, Kalle, Christof von, Ast, Volker, Lawerenz, Christian, Eils, Jürgen, Betts, Matthew J., Russell, Robert B., Roggendorf, Wolfgang, Unterberg, Andreas, Herold-Mende, Christel, Milde, Till, Kulozik, Andreas, Deimling, Andreas von, Witt, Olaf, Rutkowski, Stefan, Bueren, André von, Brors, Benedikt, Korbel, Jan Oliver, Korshunov, Andrey, Eils, Roland, Pfister, Stefan, Lichter, Peter
author_facet Jones, David T. W., Jäger, Natalie, Kool, Marcel, Zichner, Thomas, Hutter, Barbara, Sultan, Marc, Cho, Yoon-Jae, Pugh, Trevor, Hovestadt, Volker, Stütz, Adrian M., Rausch, Tobias, Warnatz, Hans-Jörg, Ryzhova, Marina, Bender, Sebastian, Sturm, Dominik, Pleier, Sabrina Valesca, Şeker-Cin, Huriye, Pfaff, Elke Katrin, Sieber, Laura, Wittmann, Andrea, Remke, Marc, Witt, Hendrik, Hutter, Sonja, Tzaridis, Theophilos-Dimitrios, Weischenfeldt, Joachim, Zapatka, Marc, Bartholomä, Cynthia C., Schmidt, Manfred, Kalle, Christof von, Ast, Volker, Lawerenz, Christian, Eils, Jürgen, Betts, Matthew J., Russell, Robert B., Roggendorf, Wolfgang, Unterberg, Andreas, Herold-Mende, Christel, Milde, Till, Kulozik, Andreas, Deimling, Andreas von, Witt, Olaf, Rutkowski, Stefan, Bueren, André von, Brors, Benedikt, Korbel, Jan Oliver, Korshunov, Andrey, Eils, Roland, Pfister, Stefan, Lichter, Peter
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container_reference 488(2012), 7409, Seite 100-105
container_title Nature <London>
contents Medulloblastoma is an aggressively growing tumour, arising in the cerebellum or medulla/brain stem. It is the most common malignant brain tumour in children, and shows tremendous biological and clinical heterogeneity1. Despite recent treatment advances, approximately 40% of children experience tumour recurrence, and 30% will die from their disease. Those who survive often have a significantly reduced quality of life. Four tumour subgroups with distinct clinical, biological and genetic profiles are currently identified2,3. WNT tumours, showing activated wingless pathway signalling, carry a favourable prognosis under current treatment regimens4. SHH tumours show hedgehog pathway activation, and have an intermediate prognosis2. Group 3 and 4 tumours are molecularly less well characterized, and also present the greatest clinical challenges2,3,5. The full repertoire of genetic events driving this distinction, however, remains unclear. Here we describe an integrative deep-sequencing analysis of 125 tumour-normal pairs, conducted as part of the International Cancer Genome Consortium (ICGC) PedBrain Tumor Project. Tetraploidy was identified as a frequent early event in Group 3 and 4 tumours, and a positive correlation between patient age and mutation rate was observed. Several recurrent mutations were identified, both in known medulloblastoma-related genes (CTNNB1, PTCH1, MLL2, SMARCA4) and in genes not previously linked to this tumour (DDX3X, CTDNEP1, KDM6A, TBR1), often in subgroup-specific patterns. RNA sequencing confirmed these alterations, and revealed the expression of what are, to our knowledge, the first medulloblastoma fusion genes identified. Chromatin modifiers were frequently altered across all subgroups. These findings enhance our understanding of the genomic complexity and heterogeneity underlying medulloblastoma, and provide several potential targets for new therapeutics, especially for Group 3 and 4 patients.
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spelling Jones, David T. W. VerfasserIn (DE-588)1058669672 (DE-627)79739334X (DE-576)414823583 aut, Dissecting the genomic complexity underlying medulloblastoma David T.W. Jones, Natalie Jäger, Marcel Kool, Thomas Zichner, Barbara Hutter, Marc Sultan, Yoon-Jae Cho, Trevor J. Pugh, Volker Hovestadt, Adrian M. Stütz, Tobias Rausch, Hans-Jörg Warnatz, Marina Ryzhova, Sebastian Bender, Dominik Sturm, Sabrina Pleier, Huriye Cin, Elke Pfaff, Laura Sieber, Andrea Wittmann, Marc Remke, Hendrik Witt, Sonja Hutter, Theophilos Tzaridis, Joachim Weischenfeldt, Benjamin Raeder, Meryem Avci, Vyacheslav Amstislavskiy, Marc Zapatka, Ursula D. Weber, Qi Wang, Bärbel Lasitschka, Cynthia C. Bartholomae, Manfred Schmidt, Christof von Kalle, Volker Ast, Chris Lawerenz, Jürgen Eils, Rolf Kabbe, Vladimir Benes, Peter van Sluis, Jan Koster, Richard Volckmann, David Shih, Matthew J. Betts, Robert B. Russell, Simona Coco, Gian Paolo Tonini, Ulrich Schüller, Volkmar Hans, Norbert Graf, Yoo-Jin Kim, Camelia Monoranu, Wolfgang Roggendorf, Andreas Unterberg, Christel Herold-Mende, Till Milde, Andreas E. Kulozik, Andreas von Deimling, Olaf Witt, Eberhard Maass, Jochen Rössler, Martin Ebinger, Martin U. Schuhmann, Michael C. Frühwald, Martin Hasselblatt, Nada Jabado, Stefan Rutkowski, André O. von Bueren, Dan Williamson, Steven C. Clifford, Martin G. McCabe, V. Peter Collins, Stephan Wolf, Stefan Wiemann, Hans Lehrach, Benedikt Brors, Wolfram Scheurlen, Jörg Felsberg, Guido Reifenberger, Paul A. Northcott, Michael D. Taylor, Matthew Meyerson, Scott L. Pomeroy, Marie-Laure Yaspo, Jan O. Korbel, Andrey Korshunov, Roland Eils, Stefan M. Pfister, Peter Lichter, 25 July 2012, 6, Text txt rdacontent, Computermedien c rdamedia, Online-Ressource cr rdacarrier, Gesehen am 20.08.2018, Medulloblastoma is an aggressively growing tumour, arising in the cerebellum or medulla/brain stem. It is the most common malignant brain tumour in children, and shows tremendous biological and clinical heterogeneity1. Despite recent treatment advances, approximately 40% of children experience tumour recurrence, and 30% will die from their disease. Those who survive often have a significantly reduced quality of life. Four tumour subgroups with distinct clinical, biological and genetic profiles are currently identified2,3. WNT tumours, showing activated wingless pathway signalling, carry a favourable prognosis under current treatment regimens4. SHH tumours show hedgehog pathway activation, and have an intermediate prognosis2. Group 3 and 4 tumours are molecularly less well characterized, and also present the greatest clinical challenges2,3,5. The full repertoire of genetic events driving this distinction, however, remains unclear. Here we describe an integrative deep-sequencing analysis of 125 tumour-normal pairs, conducted as part of the International Cancer Genome Consortium (ICGC) PedBrain Tumor Project. Tetraploidy was identified as a frequent early event in Group 3 and 4 tumours, and a positive correlation between patient age and mutation rate was observed. Several recurrent mutations were identified, both in known medulloblastoma-related genes (CTNNB1, PTCH1, MLL2, SMARCA4) and in genes not previously linked to this tumour (DDX3X, CTDNEP1, KDM6A, TBR1), often in subgroup-specific patterns. RNA sequencing confirmed these alterations, and revealed the expression of what are, to our knowledge, the first medulloblastoma fusion genes identified. Chromatin modifiers were frequently altered across all subgroups. These findings enhance our understanding of the genomic complexity and heterogeneity underlying medulloblastoma, and provide several potential targets for new therapeutics, especially for Group 3 and 4 patients., Jäger, Natalie VerfasserIn (DE-588)1057941662 (DE-627)795556195 (DE-576)413944638 aut, Kool, Marcel VerfasserIn (DE-588)1058669753 (DE-627)797393560 (DE-576)414823842 aut, Zichner, Thomas VerfasserIn (DE-588)1057945439 (DE-627)795562152 (DE-576)413950794 aut, Hutter, Barbara VerfasserIn (DE-588)14009752X (DE-627)61602293X (DE-576)314588760 aut, Sultan, Marc 1975- VerfasserIn (DE-588)133005135 (DE-627)530085771 (DE-576)299558908 aut, Cho, Yoon-Jae VerfasserIn aut, Pugh, Trevor VerfasserIn (DE-588)1172302219 (DE-627)1041103832 (DE-576)514493461 aut, Hovestadt, Volker VerfasserIn (DE-588)1075291089 (DE-627)833134264 (DE-576)443370516 aut, Stütz, Adrian M. VerfasserIn (DE-588)1070502332 (DE-627)823965163 (DE-576)430151276 aut, Rausch, Tobias VerfasserIn (DE-588)1111817340 (DE-627)865922772 (DE-576)476285496 aut, Warnatz, Hans-Jörg 1974- VerfasserIn (DE-588)140611363 (DE-627)620230274 (DE-576)319093115 aut, Ryzhova, Marina VerfasserIn (DE-588)1211521982 (DE-627)169981130X aut, Bender, Sebastian VerfasserIn (DE-588)1034990187 (DE-627)74660596X (DE-576)382607112 aut, Sturm, Dominik 1983- VerfasserIn (DE-588)1035550709 (DE-627)749549165 (DE-576)383282144 aut, Pleier, Sabrina Valesca VerfasserIn (DE-588)1028602790 (DE-627)731314743 (DE-576)376096632 aut, Şeker-Cin, Huriye VerfasserIn (DE-588)1083854712 (DE-627)848056949 (DE-576)455756902 aut, Pfaff, Elke Katrin 1985- VerfasserIn (DE-588)1037262174 (DE-627)755739728 (DE-576)39127614X aut, Sieber, Laura VerfasserIn (DE-588)1208218352 (DE-627)1694427897 aut, Wittmann, Andrea 1970- VerfasserIn (DE-588)121116484 (DE-627)705238172 (DE-576)292545061 aut, Remke, Marc 1981- VerfasserIn (DE-588)140368787 (DE-627)618255133 (DE-576)316618179 aut, Witt, Hendrik VerfasserIn (DE-588)1043235884 (DE-627)770439373 (DE-576)394592085 aut, Hutter, Sonja VerfasserIn (DE-588)1081213809 (DE-627)845695657 (DE-576)454045840 aut, Tzaridis, Theophilos-Dimitrios 1988- VerfasserIn (DE-588)1101606789 (DE-627)859784010 (DE-576)469970367 aut, Weischenfeldt, Joachim VerfasserIn (DE-588)1225427894 (DE-627)1745084029 aut, Zapatka, Marc 1974- VerfasserIn (DE-588)128629975 (DE-627)376935782 (DE-576)297249320 aut, Bartholomä, Cynthia C. VerfasserIn (DE-588)1036481042 (DE-627)751079243 (DE-576)384489524 aut, Schmidt, Manfred 1967- VerfasserIn (DE-588)122922301 (DE-627)706092430 (DE-576)293477620 aut, Kalle, Christof von 1962- VerfasserIn (DE-588)1036481115 (DE-627)75107926X (DE-576)168957396 aut, Ast, Volker 1981- VerfasserIn (DE-588)1204667705 (DE-627)1690077794 aut, Lawerenz, Christian VerfasserIn (DE-588)1182053327 (DE-627)1662547374 aut, Eils, Jürgen VerfasserIn (DE-588)1036224325 (DE-627)749759399 (DE-576)383714753 aut, Betts, Matthew J. VerfasserIn (DE-588)1050283740 (DE-627)78378127X (DE-576)404498930 aut, Russell, Robert B. VerfasserIn (DE-588)173751091 (DE-627)698656334 (DE-576)134591755 aut, Roggendorf, Wolfgang VerfasserIn (DE-588)1018926062 (DE-627)690725469 (DE-576)356626768 aut, Unterberg, Andreas VerfasserIn (DE-588)1032681187 (DE-627)738641200 (DE-576)168441233 aut, Herold-Mende, Christel VerfasserIn (DE-588)1022936549 (DE-627)717335577 (DE-576)366194267 aut, Milde, Till VerfasserIn (DE-588)1038311837 (DE-627)75711234X (DE-576)39229334X aut, Kulozik, Andreas 1959- VerfasserIn (DE-588)1025736567 (DE-627)723892032 (DE-576)167091638 aut, Deimling, Andreas von 1959- VerfasserIn (DE-588)103034115X (DE-627)735093946 (DE-576)378138065 aut, Witt, Olaf 1965- VerfasserIn (DE-588)17275030X (DE-627)697681750 (DE-576)133607410 aut, Rutkowski, Stefan 1965- VerfasserIn (DE-588)114616108 (DE-627)527107506 (DE-576)289803004 aut, Bueren, André von VerfasserIn (DE-588)1027425445 (DE-627)729125017 (DE-576)373208502 aut, Brors, Benedikt VerfasserIn (DE-588)1112102965 (DE-627)866068732 (DE-576)476376157 aut, Korbel, Jan Oliver 1975- VerfasserIn (DE-588)130346500 (DE-627)499578031 (DE-576)298140969 aut, Korshunov, Andrey VerfasserIn (DE-588)1043235361 (DE-627)770439365 (DE-576)394592093 aut, Eils, Roland 1965- VerfasserIn (DE-588)1020648287 (DE-627)691291705 (DE-576)361718195 aut, Pfister, Stefan 1974- VerfasserIn (DE-588)123850215 (DE-627)706450930 (DE-576)293908400 aut, Lichter, Peter 1957- VerfasserIn (DE-588)1096366282 (DE-627)856749915 (DE-576)468019049 aut, Enthalten in Nature <London> London [u.a.] : Nature Publ. Group, 1869 488(2012), 7409, Seite 100-105 Online-Ressource (DE-627)240151402 (DE-600)1413423-8 (DE-576)079718426 1476-4687 nnns, volume:488 year:2012 number:7409 pages:100-105 extent:6, Erscheint auch als Druck-Ausgabe Jones, David T. W. Dissecting the genomic complexity underlying medulloblastoma 2012 (DE-627)778408469 (DE-576)9778408467, http://dx.doi.org/10.1038/nature11284 Verlag Resolving-System kostenfrei Volltext, https://www.nature.com/articles/nature11284 Verlag kostenfrei Volltext, http://dx.doi.org/10.1038/nature11284 LFER, LFER 2018-09-13T00:00:00Z
spellingShingle Jones, David T. W., Jäger, Natalie, Kool, Marcel, Zichner, Thomas, Hutter, Barbara, Sultan, Marc, Cho, Yoon-Jae, Pugh, Trevor, Hovestadt, Volker, Stütz, Adrian M., Rausch, Tobias, Warnatz, Hans-Jörg, Ryzhova, Marina, Bender, Sebastian, Sturm, Dominik, Pleier, Sabrina Valesca, Şeker-Cin, Huriye, Pfaff, Elke Katrin, Sieber, Laura, Wittmann, Andrea, Remke, Marc, Witt, Hendrik, Hutter, Sonja, Tzaridis, Theophilos-Dimitrios, Weischenfeldt, Joachim, Zapatka, Marc, Bartholomä, Cynthia C., Schmidt, Manfred, Kalle, Christof von, Ast, Volker, Lawerenz, Christian, Eils, Jürgen, Betts, Matthew J., Russell, Robert B., Roggendorf, Wolfgang, Unterberg, Andreas, Herold-Mende, Christel, Milde, Till, Kulozik, Andreas, Deimling, Andreas von, Witt, Olaf, Rutkowski, Stefan, Bueren, André von, Brors, Benedikt, Korbel, Jan Oliver, Korshunov, Andrey, Eils, Roland, Pfister, Stefan, Lichter, Peter, Dissecting the genomic complexity underlying medulloblastoma, Medulloblastoma is an aggressively growing tumour, arising in the cerebellum or medulla/brain stem. It is the most common malignant brain tumour in children, and shows tremendous biological and clinical heterogeneity1. Despite recent treatment advances, approximately 40% of children experience tumour recurrence, and 30% will die from their disease. Those who survive often have a significantly reduced quality of life. Four tumour subgroups with distinct clinical, biological and genetic profiles are currently identified2,3. WNT tumours, showing activated wingless pathway signalling, carry a favourable prognosis under current treatment regimens4. SHH tumours show hedgehog pathway activation, and have an intermediate prognosis2. Group 3 and 4 tumours are molecularly less well characterized, and also present the greatest clinical challenges2,3,5. The full repertoire of genetic events driving this distinction, however, remains unclear. Here we describe an integrative deep-sequencing analysis of 125 tumour-normal pairs, conducted as part of the International Cancer Genome Consortium (ICGC) PedBrain Tumor Project. Tetraploidy was identified as a frequent early event in Group 3 and 4 tumours, and a positive correlation between patient age and mutation rate was observed. Several recurrent mutations were identified, both in known medulloblastoma-related genes (CTNNB1, PTCH1, MLL2, SMARCA4) and in genes not previously linked to this tumour (DDX3X, CTDNEP1, KDM6A, TBR1), often in subgroup-specific patterns. RNA sequencing confirmed these alterations, and revealed the expression of what are, to our knowledge, the first medulloblastoma fusion genes identified. Chromatin modifiers were frequently altered across all subgroups. These findings enhance our understanding of the genomic complexity and heterogeneity underlying medulloblastoma, and provide several potential targets for new therapeutics, especially for Group 3 and 4 patients.
swb_id_str 510217680
title Dissecting the genomic complexity underlying medulloblastoma
title_auth Dissecting the genomic complexity underlying medulloblastoma
title_full Dissecting the genomic complexity underlying medulloblastoma David T.W. Jones, Natalie Jäger, Marcel Kool, Thomas Zichner, Barbara Hutter, Marc Sultan, Yoon-Jae Cho, Trevor J. Pugh, Volker Hovestadt, Adrian M. Stütz, Tobias Rausch, Hans-Jörg Warnatz, Marina Ryzhova, Sebastian Bender, Dominik Sturm, Sabrina Pleier, Huriye Cin, Elke Pfaff, Laura Sieber, Andrea Wittmann, Marc Remke, Hendrik Witt, Sonja Hutter, Theophilos Tzaridis, Joachim Weischenfeldt, Benjamin Raeder, Meryem Avci, Vyacheslav Amstislavskiy, Marc Zapatka, Ursula D. Weber, Qi Wang, Bärbel Lasitschka, Cynthia C. Bartholomae, Manfred Schmidt, Christof von Kalle, Volker Ast, Chris Lawerenz, Jürgen Eils, Rolf Kabbe, Vladimir Benes, Peter van Sluis, Jan Koster, Richard Volckmann, David Shih, Matthew J. Betts, Robert B. Russell, Simona Coco, Gian Paolo Tonini, Ulrich Schüller, Volkmar Hans, Norbert Graf, Yoo-Jin Kim, Camelia Monoranu, Wolfgang Roggendorf, Andreas Unterberg, Christel Herold-Mende, Till Milde, Andreas E. Kulozik, Andreas von Deimling, Olaf Witt, Eberhard Maass, Jochen Rössler, Martin Ebinger, Martin U. Schuhmann, Michael C. Frühwald, Martin Hasselblatt, Nada Jabado, Stefan Rutkowski, André O. von Bueren, Dan Williamson, Steven C. Clifford, Martin G. McCabe, V. Peter Collins, Stephan Wolf, Stefan Wiemann, Hans Lehrach, Benedikt Brors, Wolfram Scheurlen, Jörg Felsberg, Guido Reifenberger, Paul A. Northcott, Michael D. Taylor, Matthew Meyerson, Scott L. Pomeroy, Marie-Laure Yaspo, Jan O. Korbel, Andrey Korshunov, Roland Eils, Stefan M. Pfister, Peter Lichter
title_fullStr Dissecting the genomic complexity underlying medulloblastoma David T.W. Jones, Natalie Jäger, Marcel Kool, Thomas Zichner, Barbara Hutter, Marc Sultan, Yoon-Jae Cho, Trevor J. Pugh, Volker Hovestadt, Adrian M. Stütz, Tobias Rausch, Hans-Jörg Warnatz, Marina Ryzhova, Sebastian Bender, Dominik Sturm, Sabrina Pleier, Huriye Cin, Elke Pfaff, Laura Sieber, Andrea Wittmann, Marc Remke, Hendrik Witt, Sonja Hutter, Theophilos Tzaridis, Joachim Weischenfeldt, Benjamin Raeder, Meryem Avci, Vyacheslav Amstislavskiy, Marc Zapatka, Ursula D. Weber, Qi Wang, Bärbel Lasitschka, Cynthia C. Bartholomae, Manfred Schmidt, Christof von Kalle, Volker Ast, Chris Lawerenz, Jürgen Eils, Rolf Kabbe, Vladimir Benes, Peter van Sluis, Jan Koster, Richard Volckmann, David Shih, Matthew J. Betts, Robert B. Russell, Simona Coco, Gian Paolo Tonini, Ulrich Schüller, Volkmar Hans, Norbert Graf, Yoo-Jin Kim, Camelia Monoranu, Wolfgang Roggendorf, Andreas Unterberg, Christel Herold-Mende, Till Milde, Andreas E. Kulozik, Andreas von Deimling, Olaf Witt, Eberhard Maass, Jochen Rössler, Martin Ebinger, Martin U. Schuhmann, Michael C. Frühwald, Martin Hasselblatt, Nada Jabado, Stefan Rutkowski, André O. von Bueren, Dan Williamson, Steven C. Clifford, Martin G. McCabe, V. Peter Collins, Stephan Wolf, Stefan Wiemann, Hans Lehrach, Benedikt Brors, Wolfram Scheurlen, Jörg Felsberg, Guido Reifenberger, Paul A. Northcott, Michael D. Taylor, Matthew Meyerson, Scott L. Pomeroy, Marie-Laure Yaspo, Jan O. Korbel, Andrey Korshunov, Roland Eils, Stefan M. Pfister, Peter Lichter
title_full_unstemmed Dissecting the genomic complexity underlying medulloblastoma David T.W. Jones, Natalie Jäger, Marcel Kool, Thomas Zichner, Barbara Hutter, Marc Sultan, Yoon-Jae Cho, Trevor J. Pugh, Volker Hovestadt, Adrian M. Stütz, Tobias Rausch, Hans-Jörg Warnatz, Marina Ryzhova, Sebastian Bender, Dominik Sturm, Sabrina Pleier, Huriye Cin, Elke Pfaff, Laura Sieber, Andrea Wittmann, Marc Remke, Hendrik Witt, Sonja Hutter, Theophilos Tzaridis, Joachim Weischenfeldt, Benjamin Raeder, Meryem Avci, Vyacheslav Amstislavskiy, Marc Zapatka, Ursula D. Weber, Qi Wang, Bärbel Lasitschka, Cynthia C. Bartholomae, Manfred Schmidt, Christof von Kalle, Volker Ast, Chris Lawerenz, Jürgen Eils, Rolf Kabbe, Vladimir Benes, Peter van Sluis, Jan Koster, Richard Volckmann, David Shih, Matthew J. Betts, Robert B. Russell, Simona Coco, Gian Paolo Tonini, Ulrich Schüller, Volkmar Hans, Norbert Graf, Yoo-Jin Kim, Camelia Monoranu, Wolfgang Roggendorf, Andreas Unterberg, Christel Herold-Mende, Till Milde, Andreas E. Kulozik, Andreas von Deimling, Olaf Witt, Eberhard Maass, Jochen Rössler, Martin Ebinger, Martin U. Schuhmann, Michael C. Frühwald, Martin Hasselblatt, Nada Jabado, Stefan Rutkowski, André O. von Bueren, Dan Williamson, Steven C. Clifford, Martin G. McCabe, V. Peter Collins, Stephan Wolf, Stefan Wiemann, Hans Lehrach, Benedikt Brors, Wolfram Scheurlen, Jörg Felsberg, Guido Reifenberger, Paul A. Northcott, Michael D. Taylor, Matthew Meyerson, Scott L. Pomeroy, Marie-Laure Yaspo, Jan O. Korbel, Andrey Korshunov, Roland Eils, Stefan M. Pfister, Peter Lichter
title_in_hierarchy Dissecting the genomic complexity underlying medulloblastoma / David T.W. Jones, Natalie Jäger, Marcel Kool, Thomas Zichner, Barbara Hutter, Marc Sultan, Yoon-Jae Cho, Trevor J. Pugh, Volker Hovestadt, Adrian M. Stütz, Tobias Rausch, Hans-Jörg Warnatz, Marina Ryzhova, Sebastian Bender, Dominik Sturm, Sabrina Pleier, Huriye Cin, Elke Pfaff, Laura Sieber, Andrea Wittmann, Marc Remke, Hendrik Witt, Sonja Hutter, Theophilos Tzaridis, Joachim Weischenfeldt, Benjamin Raeder, Meryem Avci, Vyacheslav Amstislavskiy, Marc Zapatka, Ursula D. Weber, Qi Wang, Bärbel Lasitschka, Cynthia C. Bartholomae, Manfred Schmidt, Christof von Kalle, Volker Ast, Chris Lawerenz, Jürgen Eils, Rolf Kabbe, Vladimir Benes, Peter van Sluis, Jan Koster, Richard Volckmann, David Shih, Matthew J. Betts, Robert B. Russell, Simona Coco, Gian Paolo Tonini, Ulrich Schüller, Volkmar Hans, Norbert Graf, Yoo-Jin Kim, Camelia Monoranu, Wolfgang Roggendorf, Andreas Unterberg, Christel Herold-Mende, Till Milde, Andreas E. Kulozik, Andreas von Deimling, Olaf Witt, Eberhard Maass, Jochen Rössler, Martin Ebinger, Martin U. Schuhmann, Michael C. Frühwald, Martin Hasselblatt, Nada Jabado, Stefan Rutkowski, André O. von Bueren, Dan Williamson, Steven C. Clifford, Martin G. McCabe, V. Peter Collins, Stephan Wolf, Stefan Wiemann, Hans Lehrach, Benedikt Brors, Wolfram Scheurlen, Jörg Felsberg, Guido Reifenberger, Paul A. Northcott, Michael D. Taylor, Matthew Meyerson, Scott L. Pomeroy, Marie-Laure Yaspo, Jan O. Korbel, Andrey Korshunov, Roland Eils, Stefan M. Pfister, Peter Lichter,
title_short Dissecting the genomic complexity underlying medulloblastoma
title_sort dissecting the genomic complexity underlying medulloblastoma
url http://dx.doi.org/10.1038/nature11284, https://www.nature.com/articles/nature11284