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Changes in CD73, CD39 and CD26 expression on T-lymphocytes of ANCA-associated vasculitis patients suggest impairment in adenosine generation and turn-over

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Veröffentlicht in: Scientific reports 7(2017) Artikel-Nummer 11683, 10 Seiten
Personen und Körperschaften: Kling, Simon Lovis (VerfasserIn), Benck, Urs Tobias (VerfasserIn), Breedijk, Annette (VerfasserIn), Leikeim, Lisa (VerfasserIn), Porubský, Štefan (VerfasserIn), Krämer, Bernhard (VerfasserIn), Yard, Benito A. (VerfasserIn), Kälsch, Anna-Isabelle (VerfasserIn)
Titel: Changes in CD73, CD39 and CD26 expression on T-lymphocytes of ANCA-associated vasculitis patients suggest impairment in adenosine generation and turn-over/ Lovis Kling, Urs Benck, Annette Breedijk, Lisa Leikeim, Marianne Heitzmann, Stefan Porubsky, Bernhard K. Krämer, Benito A. Yard and Anna-Isabelle Kälsch
Format: E-Book-Kapitel
Sprache: Englisch
veröffentlicht:
15 September 2017
Gesamtaufnahme: : Scientific reports, 7(2017) Artikel-Nummer 11683, 10 Seiten
, volume:7
Quelle: Verbunddaten SWB
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Zusammenfassung: Extracellular adenosine, generated via the concerted action of CD39 and CD73, contributes to T-cell differentiation and function. Adenosine concentrations are furthermore influenced by adenosine deaminase binding protein CD26. Because aberrant T-cell phenotypes had been reported in anti-neutrophil cytoplasmic auto-antibody (ANCA)-associated vasculitis (AAV) patients, an impaired expression of these molecules on T-cells of AAV patients was hypothesized in the present study. While in AAV patients (n = 29) CD26 was increased on CD4+ lymphocytes, CD39 and CD73 were generally reduced on patients’ T-cells. In CD4+ cells significant differences in CD73 expression were confined to memory CD45RA- cells, while in CD4- lymphocytes differences were significant in both naïve CD45RA+ and memory CD45RA- cells. The percentage of CD4-CD73+ cells correlated with micro-RNA (miR)−31 expression, a putative regulator of factor inhibiting hypoxia-inducible factor 1 alpha (FIH-1), inversely with serum C-reactive protein (CRP) and positively with estimated glomerular filtration rate (eGFR). No correlation with disease activity, duration, and ANCA profile was found. It remains to be assessed if a decreased CD73 and CD39 expression underlies functional impairment of lymphocytes in AAV patients. Likewise, the relations between frequencies of CD4-CD73+ cells and serum CRP or eGFR require further functional elucidation.
Beschreibung: Gesehen am 13.08.2018
Umfang: 10
ISSN: 2045-2322
DOI: 10.1038/s41598-017-12011-4