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Epstein-Barr virus particles induce centrosome amplification and chromosomal instability
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| Veröffentlicht in: | Nature Communications 8(2017) Artikel-Nummer 14257, 15 Seiten |
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| Personen und Körperschaften: | , , , , , , , , , , |
| Titel: | Epstein-Barr virus particles induce centrosome amplification and chromosomal instability/ Anatoliy Shumilov, Ming-Han Tsai, Yvonne T. Schlosser, Anne-Sophie Kratz, Katharina Bernhardt, Susanne Fink, Tuba Mizani, Xiaochen Lin, Anna Jauch, Josef Mautner, Annette Kopp-Schneider, Regina Feederle, Ingrid Hoffmann and Henri-Jacques Delecluse |
| Format: | E-Book-Kapitel |
| Sprache: | Englisch |
| veröffentlicht: |
10 Feb 2017
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| Gesamtaufnahme: |
: Nature Communications, 8(2017) Artikel-Nummer 14257, 15 Seiten
, volume:8 |
| Quelle: | Verbunddaten SWB Lizenzfreie Online-Ressourcen |
| Zusammenfassung: | Infections with Epstein-Barr virus (EBV) are associated with cancer development, and EBV lytic replication (the process that generates virus progeny) is a strong risk factor for some cancer types. Here we report that EBV infection of B-lymphocytes (in vitro and in a mouse model) leads to an increased rate of centrosome amplification, associated with chromosomal instability. This effect can be reproduced with virus-like particles devoid of EBV DNA, but not with defective virus-like particles that cannot infect host cells. Viral protein BNRF1 induces centrosome amplification, and BNRF1-deficient viruses largely lose this property. These findings identify a new mechanism by which EBV particles can induce chromosomal instability without establishing a chronic infection, thereby conferring a risk for development of tumours that do not necessarily carry the viral genome. |
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| Beschreibung: | Gesehen am 08.08.2018 |
| Umfang: | 15 |
| ISSN: |
2041-1723
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| DOI: | 10.1038/ncomms14257 |