Protection from experimental cerebral malaria with a single intravenous or subcutaneous whole-parasite immunization

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Veröffentlicht in:	Scientific reports 8(2018) Artikel-Nummer 3085, 10 Seiten
Personen und Körperschaften:	Heiß, Kirsten (VerfasserIn), Maier, Marion Irmgard (VerfasserIn), Hoffmann, Angelika (VerfasserIn), Frank, Roland (VerfasserIn), Bendszus, Martin (VerfasserIn), Müller, Ann-Kristin (VerfasserIn), Pfeil, Johannes (VerfasserIn)
Titel:	Protection from experimental cerebral malaria with a single intravenous or subcutaneous whole-parasite immunization/ Kirsten Heiss, Marion Irmgard Maier, Angelika Hoffmann, Roland Frank, Martin Bendszus, Ann-Kristin Mueller & Johannes Pfeil
Format:	E-Book-Kapitel
Sprache:	Englisch
veröffentlicht:	15 February 2018
Gesamtaufnahme:	: Scientific reports, 8(2018) Artikel-Nummer 3085, 10 Seiten , volume:8
Quelle:	Verbunddaten SWB Lizenzfreie Online-Ressourcen

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Zusammenfassung:	Cerebral malaria is a life-threatening complication of Plasmodia infection and a major cause of child mortality in Sub-Saharan Africa. We report that protection from experimental cerebral malaria in the rodent model is obtained by a single intravenous or subcutaneous whole-parasite immunization. Whole-parasite immunization with radiation-attenuated sporozoites was equally protective as immunization with non-attenuated sporozoites under chemoprophylaxis. Both immunization regimens delayed the development of blood-stage parasites, but differences in cellular and humoral immune mechanisms were observed. Single-dose whole-parasite vaccination might serve as a relatively simple and feasible immunization approach to prevent life-threatening cerebral malaria.
Beschreibung:	Gesehen am 19.07.2018
Umfang:	10
ISSN:	2045-2322
DOI:	10.1038/s41598-018-21551-2