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Percutaneous closure of left atrial appendage affects mid-term release of MR-proANP

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Veröffentlicht in: Scientific reports extent:6; volume:7; 7(2017) Artikel-Nummer 9028, 6 Seiten; year:2017
Personen und Körperschaften: Behnes, Michael (VerfasserIn), Sartorius, Benjamin (VerfasserIn), Wenke, Annika (VerfasserIn), Lang, Siegfried (VerfasserIn), Hoffmann, Ursula (VerfasserIn), Fastner, Christian (VerfasserIn), Borggrefe, Martin (VerfasserIn), Akın, Ibrahim (VerfasserIn)
Titel: Percutaneous closure of left atrial appendage affects mid-term release of MR-proANP/ Michael Behnes, Benjamin Sartorius, Annika Wenke, Siegfried Lang, Ursula Hoffmann, Christian Fastner, Martin Borggrefe, Thomas Roth, Jakob Triebel, Thomas Bertsch, Ibrahim Akin
Format: E-Book-Kapitel
Sprache: Englisch
veröffentlicht:
2017
Gesamtaufnahme: : Scientific reports, 7(2017) Artikel-Nummer 9028, 6 Seiten
, volume:7
Quelle: Verbunddaten SWB
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Zusammenfassung: The left atrial appendage (LAA) represents both a predisposing source of thrombus formation and of neuro-humoral haemostasis. This study aims to evaluate changes of biomarker expression before and after successful percutaneous closure of the LAA. Patients with atrial fibrillation and contraindication for oral anticoagulant therapy were enrolled. Blood samples were taken within 24 hours before (T1) and at least 6 months (mid-term) (T2) after successful implantation of LAA occlusion devices. Blood levels of high sensitivity troponin I and T (hsTnI, hsTnT), aminoterminal pro-brain natriuretic peptide (NT-proBNP) and mid-regional pro-atrial natriuretic peptide (MR-proANP) were evaluated at both time points. A total of 42 patients with successful percutaneous LAA closure were included. Median mid-term follow-up was of 183 days. HsTnT, hsTnI and NT-proBNP did not show any significant differences over time. Serum levels of MR-proANP increased significantly between immediate pre-intervention (T1: median = 245.7 pmol/l, IQR 155.8-361.3 pmol/l) and at mid-term follow-up (T2: median = 254 pmol/l, IQR 183.4-396.4 pmol/l) (p = 0.037). These results indicate, that percutaneous LAA closure affects neuro-humoral haemostasis by increasing MR-proANP serum levels at mid-term follow-up.
Beschreibung: Published online: 22 August 2017
Gesehen am 29.06.2018
Umfang: 6
ISSN: 2045-2322
DOI: 10.1038/s41598-017-08999-4