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Junb controls lymphatic vascular development in zebrafish via miR-182
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| Veröffentlicht in: | Scientific reports 5(2015) Artikel-Nummer 15007, 16 Seiten |
|---|---|
| Personen und Körperschaften: | , , , |
| Titel: | Junb controls lymphatic vascular development in zebrafish via miR-182/ Kristin Kiesow, Katrin Bennewitz, Laura Gutierrez Miranda, Sandra J. Stoll, Bettina Hartenstein, Peter Angel, Jens Kroll, Marina Schorpp-Kistner |
| Format: | E-Book-Kapitel |
| Sprache: | Englisch |
| veröffentlicht: |
13 October 2015
|
| Gesamtaufnahme: |
: Scientific reports, 5(2015) Artikel-Nummer 15007, 16 Seiten
, volume:5 |
| Quelle: | Verbunddaten SWB Lizenzfreie Online-Ressourcen |
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| contents | JUNB, a subunit of the AP-1 transcription factor complex, mediates gene regulation in response to a plethora of extracellular stimuli. Previously, JUNB was shown to act as a critical positive regulator of blood vessel development and homeostasis as well as a negative regulator of proliferation, inflammation and tumour growth. Here, we demonstrate that the oncogenic miR-182 is a novel JUNB target. Loss-of-function studies by morpholino-mediated knockdown and the CRISPR/Cas9 technology identify a novel function for both JUNB and its target miR-182 in lymphatic vascular development in zebrafish. Furthermore, we show that miR-182 attenuates foxo1 expression indicating that strictly balanced Foxo1 levels are required for proper lymphatic vascular development in zebrafish. In conclusion, our findings uncover with the Junb/miR-182/Foxo1 regulatory axis a novel key player in governing lymphatic vascular morphogenesis in zebrafish. |
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| spelling | Kiesow, Kristin VerfasserIn (DE-588)1034790447 (DE-627)746284640 (DE-576)381588726 aut, Junb controls lymphatic vascular development in zebrafish via miR-182 Kristin Kiesow, Katrin Bennewitz, Laura Gutierrez Miranda, Sandra J. Stoll, Bettina Hartenstein, Peter Angel, Jens Kroll, Marina Schorpp-Kistner, 13 October 2015, 16, Text txt rdacontent, Computermedien c rdamedia, Online-Ressource cr rdacarrier, Gesehen am 15.03.2018, JUNB, a subunit of the AP-1 transcription factor complex, mediates gene regulation in response to a plethora of extracellular stimuli. Previously, JUNB was shown to act as a critical positive regulator of blood vessel development and homeostasis as well as a negative regulator of proliferation, inflammation and tumour growth. Here, we demonstrate that the oncogenic miR-182 is a novel JUNB target. Loss-of-function studies by morpholino-mediated knockdown and the CRISPR/Cas9 technology identify a novel function for both JUNB and its target miR-182 in lymphatic vascular development in zebrafish. Furthermore, we show that miR-182 attenuates foxo1 expression indicating that strictly balanced Foxo1 levels are required for proper lymphatic vascular development in zebrafish. In conclusion, our findings uncover with the Junb/miR-182/Foxo1 regulatory axis a novel key player in governing lymphatic vascular morphogenesis in zebrafish., Bennewitz, Katrin 1981- VerfasserIn (DE-588)1154553140 (DE-627)1015942172 (DE-576)501101209 aut, Cramer-Stoll, Sandra 1983- VerfasserIn (DE-588)1019276096 (DE-627)684607786 (DE-576)357401212 aut, Kroll, Jens 1969- VerfasserIn (DE-588)1032295619 (DE-627)738209503 (DE-576)379947544 aut, Enthalten in Scientific reports [London] : Macmillan Publishers Limited, part of Springer Nature, 2011 5(2015) Artikel-Nummer 15007, 16 Seiten Online-Ressource (DE-627)663366712 (DE-600)2615211-3 (DE-576)346641179 2045-2322 nnns, volume:5 year:2015 extent:16, http://dx.doi.org/10.1038/srep15007 Verlag Resolving-System kostenfrei Volltext, https://www.nature.com/articles/srep15007 Verlag kostenfrei Volltext, http://dx.doi.org/10.1038/srep15007 LFER, LFER 2018-04-10T00:00:00Z |
| spellingShingle | Kiesow, Kristin, Bennewitz, Katrin, Cramer-Stoll, Sandra, Kroll, Jens, Junb controls lymphatic vascular development in zebrafish via miR-182, JUNB, a subunit of the AP-1 transcription factor complex, mediates gene regulation in response to a plethora of extracellular stimuli. Previously, JUNB was shown to act as a critical positive regulator of blood vessel development and homeostasis as well as a negative regulator of proliferation, inflammation and tumour growth. Here, we demonstrate that the oncogenic miR-182 is a novel JUNB target. Loss-of-function studies by morpholino-mediated knockdown and the CRISPR/Cas9 technology identify a novel function for both JUNB and its target miR-182 in lymphatic vascular development in zebrafish. Furthermore, we show that miR-182 attenuates foxo1 expression indicating that strictly balanced Foxo1 levels are required for proper lymphatic vascular development in zebrafish. In conclusion, our findings uncover with the Junb/miR-182/Foxo1 regulatory axis a novel key player in governing lymphatic vascular morphogenesis in zebrafish. |
| swb_id_str | 501101187 |
| title | Junb controls lymphatic vascular development in zebrafish via miR-182 |
| title_auth | Junb controls lymphatic vascular development in zebrafish via miR-182 |
| title_full | Junb controls lymphatic vascular development in zebrafish via miR-182 Kristin Kiesow, Katrin Bennewitz, Laura Gutierrez Miranda, Sandra J. Stoll, Bettina Hartenstein, Peter Angel, Jens Kroll, Marina Schorpp-Kistner |
| title_fullStr | Junb controls lymphatic vascular development in zebrafish via miR-182 Kristin Kiesow, Katrin Bennewitz, Laura Gutierrez Miranda, Sandra J. Stoll, Bettina Hartenstein, Peter Angel, Jens Kroll, Marina Schorpp-Kistner |
| title_full_unstemmed | Junb controls lymphatic vascular development in zebrafish via miR-182 Kristin Kiesow, Katrin Bennewitz, Laura Gutierrez Miranda, Sandra J. Stoll, Bettina Hartenstein, Peter Angel, Jens Kroll, Marina Schorpp-Kistner |
| title_in_hierarchy | Junb controls lymphatic vascular development in zebrafish via miR-182 / Kristin Kiesow, Katrin Bennewitz, Laura Gutierrez Miranda, Sandra J. Stoll, Bettina Hartenstein, Peter Angel, Jens Kroll, Marina Schorpp-Kistner, |
| title_short | Junb controls lymphatic vascular development in zebrafish via miR-182 |
| title_sort | junb controls lymphatic vascular development in zebrafish via mir 182 |
| url | http://dx.doi.org/10.1038/srep15007, https://www.nature.com/articles/srep15007 |